Study of cytogenetical effects of chemotherapeutic agents Mitomycin C and Cisplatin on normal Somatic and Germ cells: An in vivo study

The chemotherapeutic drugs available in the market are not specified to eliminate only cancer cells but leads to numerous toxic physical, cytogenetical and physiological side effects. Since the common target of all anticancer drugs is to decrease the growth rate (cell division) of the cancer cells, the side effects are observed in bodily systems that naturally have a rapid turnover of cells including skin, hair, gastro-intestinal, and bone marrow. Hence the healthy, normal, proliferative cells of the body also get targeted by the chemotherapy program. In this study we have observed the cytogenetical consequence induced by two most commonly administered chemotherapeutic agents Mitomycin C and Cisplatin. We have observed that both MMC (2 mg/kg bw) and Cis (4 mg/kg bw) administered to Balb/C mice induced significant level (P < 0.001) of chromosomal aberrations and Micronucleus at both 24 and 48 hour studies. So also study in germ cells have shown that exposure to Mitomycin C and Cisplatin induce highly significant level of sperm head abnormality in the animals.